The process mineralogy of the mine was systematically studied by XRD, XRF, optical microscope, scanning electron microscopy (SEM), and MLA analysis, and a selection scheme was proposed. The polymetallic tin-containing sulfide ore in Wenshan, Yunnan, was used as the research object. The results show that the element with the highest recovery value is tin, mainly in the form of cassiterite; the sulphide ores include magnetic pyrite, toxic sand, sphalerite and pyrite, with magnetic pyrite being the main sulphur-bearing mineral; the vein minerals are mainly chlorite, quartz and black mica; and also contain magnetite.The concentration test utilizes a combined method of "magnetic separation iron removal - 37 μm classification - coarse grain gravity - fine grain flotation" to produce fine sulfur concentrate with a S grade and recovery rate of 21.60% and 81.42%, respectively, and subsulfur concentrate with a S grade and recovery rate of 26.19% and 87.71%, respectively, with good desulfurization effect, laying the groundwork for thorough cassiterite recovery.