Abstract:A lead-zinc ore mine in Guangxi contains 0.83% of lead and 3.92% of zinc. The symbiotic relationship between minerals is complex. According to the nature of the mineral, the flotation agent system was optimized using a single-factor test and response surface combined experiment. Single-factor tests showed that the best grinding fineness for this mineral was -0.074 accounted for 80%, and the optimal dosage of ZnSO4 was 1800g/t. The response surface optimization test showed that the optimum dosage of the lead-zinc ore was CaO 2091.4688g/t, butyl xanthate 23.5520g/t, and ethylsulphur 29.6647g/t. Under this condition, the lead concentrate grade was 10.7094. % and recovery was 52.1828%. Under the agent system established in the above experiment, a closed-circuit experiment was conducted and the lead concentrate grade was 32.64%, the recovery was 48.21% and the zinc content was 12.19%.